Hazle Health Migraine Clear contains the most effective nutraceuticals presently known to help support the vascular system in the brain. These ingredients act synergistically to assist in quenching inflammation and reducing histamine and serotonin induced vasospasm. The unique formulation of Migraine Clear includes riboflavin, a common B vitamin that has been shown to be an effective prophylactic in the prevention of migraines and magnesium which is believed to impact migraines by its vasodilitory and calcium channel blocking. Included also is a synergistic collection of herbs including ginger root extract which has been shown to help prevent the vasoconstrictive trigger phase and to inhibit leukotriene and thromboxane synthesis associated with platelet aggregation. Feverfew extract inhibits the release of serotonin from platelets. This results in less vasoconstriction of blood vessels. Feverfew also regulates the production and release of inflammatory compounds. Butterbur has beneficial effects as an antispasmodic on smooth muscle. Ginkgo biloba is included due to its beneficial effects on normalizing smooth muscle vascular tone and overall circulation.